Rapid genotyping of XbaI and MspI DNA polymorphisms of the human factor VIII gene: estimation of their combined heterozygosity in the Argentinean population.
نویسندگان
چکیده
232 Haematologica/journal of hematology vol. 88(02):February 2003 shown that p73 was very frequently methylated in natural killer cell lymphomas.5 In lymphoma cell lines, methylation of p73 correlated with down-regulation of the p73 protein, and promoter demethylation led to re-expression of p73.5,7 Interestingly, our results also showed that p73 was frequently methylated in DLBC lymphoma in the stomach but not the lymph node. The significance of this in gastric lymphomagenesis merits further investigation. Finally, the significance of gene methylation in MALT/MZBC and DLBC lymphomagenesis will need to studied by demonstrating that methylation-induced gene suppression contributes to cellular growth dysregulation or transformation.
منابع مشابه
Combined analysis of the MspI and XbaI polymorphisms in intron 22 of the factor VIII gene for detection of hemophilia A in a Korean population.
To determine the usefulness of MspI/int22h-1 (intron 22 homologous region-1) polymorphism of the factor VIII gene for molecular genetic diagnosis of hemophilia A in the Korean population, MspI/intron 22 and XbaI/intron 22 polymorphisms were analyzed in 101 unrelated Korean families with severe hemophilia A. The expected heterozygosity rates of MspI/int22h-1 and XbaI/int22h-1 polymorphisms ...
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ورودعنوان ژورنال:
- Haematologica
دوره 88 2 شماره
صفحات -
تاریخ انتشار 2003